Histone deacetylases (HDACs) have been extensively studied as drug targets in neurodegenerative diseases. but less is known about their role in healthy neurons. We tested zinc-dependent HDACs using RNAi in Drosophila melanogaster and found memory deficits with RPD3 and HDAC6. We demonstrate that HDAC6 is required in both the larval and adult stages for normal olfactory memory retention. https://stilleners.shop/product-category/exterior-styling/